In any analytical method, a solvent must be chosen in such a way that it does not interfere with the study of the sample, is easily available, completely dissolves the sample, is inert, and of course, is not expensive. Of course, we can still make a list of requirements. We have the ideal for a solvent, but it may not be possible to achieve all of them in practice. Therefore, we must choose a solvent that meets the maximum significant criteria required for an ideal solvent.
Deutrated solvents
NMR spectroscopy is inactive for nuclei whose spin quantum number is not equal to 1/2. This causes differences in the behavior of isotopes in NMR.
For example, hydrogen has a spin number of 1/2, while its isotope deuterium (D) has a spin number of 0. Therefore, if we replace hydrogen with deuterium, we can get a suitable polar solvent without interference. In simpler words, this deuterium compound is invisible in the NMR spectrometer. Deuterium compounds have many applications for advanced academic research, and some other applications such as tracing the path of progress of complex chemical reactions, optimizing the properties of drugs, making highly advanced polymers up to optical fibers, etc. can be mentioned.